An implantable device for neuropsychiatric rehabilitation by chronic deep brain stimulation in freely moving rats
نویسندگان
چکیده
Successful practice of clinical deep brain stimulation (DBS) calls for basic research on the mechanisms and explorations of new indications in animals. In the article, a new implantable, single-channel, low-power miniature device is proposed, which may transmit pulses chronically into the brain nucleus of freely moving rats. The DBS system consists of an implantable pulse generator (IPG), a bipolar electrode, and an external programmer. The IPG circuit module is assembled as a 20-mm diameter circular board and fixed on a rat's skull together with an electrode and battery. The rigid electrode may make its fabrication and implantation more easy. The external programmer is designed for bidirectional communication with the IPG by a telecontrol transceiver and adjusts stimulation parameters. A biological validation was performed in which the effects of electrical stimulation in brain nucleus accumbens were detected. The programmed parameters were accurate, implant steady, and power sufficient to allow stimulation for more than 3 months. The larger area of the electrode tip provided a moderate current or charge density and minimized the damage from electrochemistry and pyroelectricity. The rats implanted with the device showed a reduction in morphine-induced conditioned place preference after high-frequency stimulation. In conclusion, the DBS device is based on the criteria of simple technology, minimal invasion, low cost, small in size, light-weight, and wireless controlled. This shows that our DBS device is appropriate and can be used for preclinical studies, indicating its potential utility in the therapy and rehabilitation of neuropsychiatric disorders.
منابع مشابه
Letter to Editor: Neuropsychiatric Consequences of Deep Brain Stimulation in Patients with Chronic Movement Disorders
متن کامل
An implantable CMOS device for functional brain imaging under freely moving experiments of rats
Observation of brain activities under freely moving condition is very important to elucidate brain functions of an animal. In this study, we developed an ultra-small implantable CMOS imaging device and successfully measured blood flow velocity of the brain surface under freely moving condition.
متن کاملThe state dependency effect of morphine on memory by behavioral and electrophysiological methods in freely moving rats
Endogenous opioid system agonists exert amnestic effects in different models of memory. It has been suggested that these amnestic effects may be linked indirectly to state-dependent learning. Accordingly pre-training administration of morphine can impair the retrieval of learned tasks in a state dependent manner, which is reversible by pre test morphine administration. In this study, state depe...
متن کاملThe state dependency effect of morphine on memory by behavioral and electrophysiological methods in freely moving rats
Endogenous opioid system agonists exert amnestic effects in different models of memory. It has been suggested that these amnestic effects may be linked indirectly to state-dependent learning. Accordingly pre-training administration of morphine can impair the retrieval of learned tasks in a state dependent manner, which is reversible by pre test morphine administration. In this study, state depe...
متن کاملOnline analysis of local field potentials for seizure detection in freely moving rats
Objective(s): Seizure detection during online recording of electrophysiological parameters is very important in epileptic patients. In the present study, online analysis of field potential recordings was used for detecting spontaneous seizures in epileptic animals.Materials and Methods: Epilepsy was induced in rats by pilocarpine injecti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 28 شماره
صفحات -
تاریخ انتشار 2017